I was rather expecting this to be a sober and gruelling tale of conflicted sexual identity. I was almost completely wrong.
Rather as Romeo and Juliet works partly because we are told up front by the Chorus that the title characters are going to die, Middlesex is absolutely clear about what is going to happen, and its charm is the clarity with which it is all laid out. I have absolutely no idea how relevant or true to life it is for readers who have themselves grappled with gender identification issues (and would be very interested to hear reactions from such quarters); it certainly raised my consciousness while also entertaining me greatly. Strongly recommended.
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I would guess either France or the UK, for rather different reasons.